Kanehisa Laboratories

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Thanks to the continuous developments of high-throughput experimental technologies since the Human Genome Project, it is now a routine task to determine the genome sequence of an organism or to obtain other types of large-scale molecular data such as metabolomics data. The KEGG resource has been developed as a reference knowledge base for understanding cellular and organism level functions from such data. It is being expanded to meet the needs of translational bioinformatics, helping the research community for translating research results into practical applications and helping society for better understanding of scientific basis of diseases and drugs.
Translational Bioinformatics
Helping to make findings gained
from genomics data useful for
practical applications
Personalized medicine
SocietyHelping to understand scientific
basis of diseases and drugs of
personal interest
Participatory medicine

KEGG MEDICUS is supported by the Database Integration Coordination Program in the NBDC Program of the Japan Science and Technology Agency.

Integrated database linking human and pathogen genomes to diseases and drugs (2022.4 - 2026.3)
We expand KEGG MEDICUS, an integrated database linking genomes to diseases and drugs through molecular networks, with advanced functionalities for utilizing genomic information in society. The disease database will be improved by associating more diseases with perturbed networks. A viral ortholog cluster database will be developed for assisting functional characterization of unknown viral genes and proteins.

Network database integrating genomes, diseases and drugs (2017.4 - 2022.3)
We develop a new reference knowledge base named KEGG NETWORK for perturbed molecular networks involving human diseases and drugs. KEGG NETWORK is a collection of network variants, such as variants of signaling pathways, caused by gene variants and other factors. We also develop a network mapping tool for interpretation of personal genome sequences.

Integrated database linking genomes to phenotypes, diseases and drugs (2014.4 - 2017.3)
In order to bring the genomic revolution to society we develop an integrated database for interpretation of genome sequence data, especially for better understanding of diseases, drug responses and drug resistance from personal genomes, pathogen genomes and metagenomes.

Genome-based integrated information resource for diseases, drugs and environmental substances (2011.4 - 2014.3)
More than twenty years ago the Human Genome Project was initiated with the promises of medical and social benefits. These promises were long overdue, but thanks to the continuous development of high-throughput experimental technologies together with improved bioinformatics technologies, the time may have finally come for bringing the genomic revolution to society. In order to meet the needs of translational bioinformatics, we develop an integrated database that links scientific knowledge on diseases, drugs and health-related substances to practical information, such as drug labels, used in society.
Kanehisa Laboratories Pathway Solutions Bioinfomatics Center