Kanehisa Laboratories

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Growth of Sequence and 3D Structure Databases

growth curve

Compiled from:
  1980-1983  Los Alamos sequence analysis system
  1983-1986  IDEAS system at the National Institutes of Health
  1986-1992  IDEAS system at Kyoto University
  1992-      DBGET system in GenomeNet database service

Databases:
  GenBank
  EMBL (until 2020.3)
  PIR (until 2004.12)
  PRF (until 2010.3)
  SWISS-PROT
  KEGG GENES
  PDB


GenBank

Release Date       Entries          Residues
--------------------------------------------
        1981/12         263          436,710  Los Alamos Sequence Library
        1982/04         315          484,813
        1982/06         403          568,083
    1   1982/10         440          601,438  GenBank first release by BBN
    2   1982/11         540          625,351
    3   1982/12         606          680,338
    4   1983/01         637          706,596
    5   1983/02         705          770,374
    6   1983/03       1,093        1,165,783
    7   1983/04       1,284        1,321,146
    8   1983/05       1,562        1,476,657
    9   1983/06       1,773        1,699,705
   10   1983/07       1,865        1,827,214
   11   1983/08       1,947        1,898,581
   12   1983/09       2,222        2,114,326
   13   1983/10       2,378        2,217,415
   14   1983/11       2,427        2,274,029
   15   1983/12       2,562        2,424,475
   16   1984/01       3,012        2,602,596
   17   1984/02       3,424        2,824,911
   18   1984/03       3,521        2,913,629
   19   1984/04       3,576        2,945,001
   20   1984/05       3,665        3,002,088
   21   1984/06       3,825        3,102,728
   22   1984/07       3,885        3,126,339
   23   1984/08       4,088        3,220,532
   24   1984/09       4,135        3,323,270
   25   1984/10       4,175        3,368,765
   26   1984/11       4,393        3,689,751
   27   1984/12       4,526        3,813,396
   28   1985/01       4,718        4,024,281
   29   1985/02       4,754        4,045,305
   30   1985/03       4,878        4,191,115
   31   1985/04       4,926        4,257,856
   32   1985/05       4,954        4,311,931
   33   1985/06       5,001        4,354,111
   34   1985/07       5,102        4,449,185
   35   1985/08       5,543        5,038,080
   36   1985/09       5,700        5,204,420
   37   1985/10       5,731        5,248,932
   38   1985/11       5,927        5,530,859
   39   1985/12       6,044        5,667,645
   40   1986/01       6,642        5,925,429
   41   1986/03       7,001        6,259,412
   42   1986/05       7,416        6,765,476
   43   1986/06       8,004        7,416,117
   44   1986/08       8,823        8,442,357
   45   1986/09       9,411        8,931,101
   46   1986/11       9,975        9,594,560
   47   1986/12      10,485       10,388,356
   48   1987/02      10,913       10,961,365
   49   1987/04      11,912       12,209,883
   50   1987/05      12,534       13,048,473
   51   1987/06      13,619       14,396,626
   52   1987/08      14,020       14,855,145
   53   1987/09      14,596       15,519,093
   54   1987/12      15,465       16,752,872  First release by IntelliGenetics
   55   1988/03      17,047       19,156,002
   56   1988/06      18,226       20,795,279
   57   1988/09      19,044       22,019,698
   58   1988/12      21,248       24,690,876
   59   1989/03      22,479       26,382,491
   60   1989/06      26,317       31,808,784
   61   1989/09      28,791       34,762,585
   62   1989/12      31,228       37,183,950
   63   1990/03      33,377       40,127,752
   64   1990/06      35,100       42,495,893
   65   1990/09      39,533       49,179,285
   66   1990/12      41,057       51,306,092
   67   1991/03      43,903       55,169,276
   68   1991/06      51,418       65,868,799
   69   1991/09      55,631       71,947,426
   70   1991/12      58,952       77,337,678
   71   1992/03      65,100       83,894,652
   72   1992/06      71,280       92,160,761
   73   1992/09      78,608      101,008,486
   74   1992/12      97,084      120,242,234  GenBank moved to NCBI
   75   1993/02     106,684      126,212,259
   76   1993/04     111,911      129,968,355
   77   1993/06     120,134      138,904,393
   78   1993/08     131,328      147,215,633
   79   1993/10     143,492      157,152,442
   80   1993/12     150,744      163,802,597
   81   1994/02     162,946      173,261,500
   82   1994/04     169,896      180,589,455
   83   1994/06     182,753      191,393,939
   84   1994/08     196,703      201,815,802
   85   1994/10     215,273      217,102,462
   86   1994/12     237,775      230,485,928
   87   1995/02     269,478      248,499,214
   88   1995/04     352,414      286,094,556
   89   1995/06     425,211      318,624,568
   90   1995/08     492,483      353,713,490
   91   1995/10     555,694      384,939,485
   92   1995/12     620,765      425,860,958
   93   1996/02     685,693      463,758,833
   94   1996/04     744,295      499,127,741
   95   1996/06     835,487      551,750,920
   96   1996/08     920,588      602,072,354
   97   1996/10   1,021,211      651,972,984
   98   1996/12   1,114,581      730,552,938
   99   1997/02   1,192,505      786,898,138
  100   1997/04   1,274,747      842,864,309
  101   1997/06   1,491,069      966,993,087
  102   1997/08   1,610,848    1,053,474,516
  103   1997/10   1,765,847    1,160,300,687
  104   1997/12   1,891,953    1,258,290,513
  105   1998/02   2,042,325    1,372,368,913
  106   1998/04   2,209,232    1,502,542,306
  107   1998/06   2,355,928    1,622,041,465
  108   1998/08   2,532,359    1,797,137,713
  109   1998/10   2,837,897    2,008,761,784
  110   1998/12   3,043,729    2,162,067,871
  111   1999/04   3,525,418    2,569,578,208
  112   1999/06   4,028,171    2,974,791,993
  113   1999/08   4,610,118    3,400,237,391
  114   1999/10   4,864,570    3,841,163,011
  115   1999/12   5,354,511    4,653,932,745
  116   2000/02   5,732,757    5,822,145,430
  117   2000/04   6,215,002    7,376,080,723
  118   2000/06   7,077,491    8,604,221,980
  119   2000/08   8,214,339    9,545,724,824
  120   2000/10   9,102,634   10,329,057,815
  121   2000/12  10,106,023   11,101,066,288
  122   2001/02  10,896,781   11,720,120,326
  123   2001/04  11,545,572   12,418,544,023
  124   2001/06  12,243,766   12,973,707,065
  125   2001/08  12,813,516   13,543,364,296
  126   2001/10  13,602,262   14,396,883,064
  127   2001/12  14,976,310   15,849,921,438
  128   2002/02  15,465,325   17,089,143,893         (WGS) 
  129   2002/04  16,769,983   19,072,679,701       172,768        692,266,338
  130   2002/06  17,471,130   20,648,748,345       397,502      3,267,608,441
  131   2002/08  18,197,119   22,616,937,182       427,771      3,848,375,582
  132   2002/10  19,808,101   26,525,934,656       434,224      3,892,435,593
  133   2002/12  22,318,883   28,507,990,166       597,042      6,702,372,564
  134   2003/02  23,035,823   29,358,082,791       597,345      6,705,740,844
  135   2003/04  24,027,936   31,099,264,455       596,818      6,897,080,355
  136   2003/06  25,592,865   32,528,249,295       607,155      6,992,663,962
  137   2003/08  27,213,748   33,865,022,251       593,801      7,144,761,762
  138   2003/10  29,819,397   35,599,621,471     1,683,437      8,662,242,833
  139   2003/12  30,968,418   36,553,368,485     2,547,094     14,523,454,868
  140   2004/02  32,549,400   37,893,844,733     3,188,754     22,804,145,885
  141   2004/04  33,676,218   38,989,342,565     4,112,532     24,758,556,215
  142   2004/06  35,532,003   40,325,321,348     4,353,890     25,592,758,366
  143   2004/08  37,343,937   41,808,045,653     4,427,773     28,128,611,847
  144   2004/10  38,941,263   43,194,602,655     5,285,276     30,871,590,379
  145   2004/12  40,604,319   44,575,745,176     5,410,415     35,009,256,228
  146   2005/02  42,734,478   46,849,831,226     6,111,782     38,076,300,084
  147   2005/04  44,202,133   48,235,738,567     6,685,746     39,523,208,346
  148   2005/06  45,236,251   49,398,852,122     8,711,924     46,767,232,565
  149   2005/08  46,947,388   51,674,486,881    10,276,161     53,346,605,784
  150   2005/10  49,152,445   53,655,236,500    11,169,448     56,162,807,647
  151   2005/12  52,016,762   56,037,734,462    12,088,491     59,638,900,034
  152   2006/02  54,584,635   59,750,386,305    12,465,546     63,183,065,091
  153   2006/04  56,620,500   61,582,143,971    13,573,144     67,488,612,571
  154   2006/06  58,890,345   63,412,609,711    17,733,973     78,858,635,822
  155   2006/08  61,132,599   65,369,091,950    17,960,667     80,369,977,826
  156   2006/10  62,765,195   66,925,938,907    18,500,772     81,127,502,509
  157   2006/12  64,893,747   69,019,290,705    18,540,918     81,611,376,856
  158   2007/02  67,218,344   71,292,211,453    19,421,576     86,043,478,524
  159   2007/04  71,802,595   75,742,041,056    23,446,831     93,022,691,867
  160   2007/06  73,078,143   77,248,690,945    23,718,400     97,102,606,459
  161   2007/08  76,146,236   79,525,559,650    25,384,475    101,964,323,738
  162   2007/10  77,632,813   81,563,399,765    25,354,041    102,003,045,298
  163   2007/12  80,388,382   83,874,179,730    26,177,471    106,505,691,578
  164   2008/02  82,853,685   85,759,586,764    27,439,206    108,635,736,141
  165   2008/04  85,500,730   89,172,350,468    26,931,049    110,500,961,400
  166   2008/06  88,554,578   92,008,611,867    39,163,548    113,639,291,344
  167   2008/08  92,748,599   95,033,791,652    40,214,247    118,593,509,342
  168   2008/10  96,400,790   97,381,682,336    46,108,952    136,085,973,423
  169   2008/12  98,868,465   99,116,431,942    48,394,838    141,374,971,004
  170   2009/02 101,815,678  101,467,270,308    49,036,947    143,797,800,446
  171   2009/04 103,335,421  102,980,268,709    48,948,309    144,522,542,010
  172   2009/06 106,073,709  105,277,306,080    49,063,546    145,959,997,864
  173   2009/08 108,431,692  106,533,156,757    48,443,067    148,165,117,763
  174   2009/10 110,946,879  108,560,236,506    48,119,301    149,348,923,035
  175   2009/12 112,910,950  110,118,557,163    54,076,973    158,317,168,385
  176   2010/02 116,461,672  112,326,229,652    57,134,273    163,991,858,015
  177   2010/04 119,112,251  114,348,888,771    58,361,599    165,536,009,514
  178   2010/06 120,604,423  115,624,497,715    58,592,700    167,725,292,032
  179   2010/08 122,941,883  117,476,523,128    58,994,334    169,253,846,128
  180   2010/10 125,764,384  118,551,641,086    59,397,637    175,339,059,129
  181   2010/12 129,902,276  122,082,812,719    59,608,311    177,385,297,156
  182   2011/02 132,015,054  124,277,818,310    62,349,795    190,034,462,797
  183   2011/04 135,440,924  126,551,501,141    62,715,288    191,401,393,188
  184   2011/06 140,482,268  129,178,292,958    63,735,078    200,487,078,184
  185   2011/08 142,284,608  130,671,233,801    64,997,137    208,315,831,132
  186   2011/10 144,458,648  132,067,413,372    68,330,215    218,666,368,056
  187   2011/12 146,413,798  135,117,731,375    73,729,553    239,868,309,609
  188   2012/02 149,819,246  137,384,889,783    78,656,704    261,370,512,675
  189   2012/04 151,824,421  139,266,481,398    80,905,298    272,693,351,548
  190   2012/06 154,130,210  141,343,240,755    82,076,779    287,577,367,116
  191   2012/08 156,424,033  143,081,765,233    84,020,064    308,196,411,905
  192   2012/10 157,889,737  145,430,961,262    86,480,509    333,881,846,451
  193   2012/12 161,140,325  148,390,863,904    92,767,765    356,002,922,838
  194   2013/02 162,886,727  150,141,354,858   103,101,291    390,900,990,416
  195   2013/04 164,136,731  151,178,979,155   110,509,314    418,026,593,606
  196   2013/06 165,740,164  152,599,230,112   112,488,036    453,829,752,320
  197   2013/08 167,295,840  154,192,921,011   124,812,020    500,420,412,665
  198   2013/10 168,335,396  155,176,494,699   130,203,205    535,842,167,741
  199   2013/12 169,331,407  156,230,531,562   133,818,571    556,764,321,498
  200   2014/02 171,123,749  157,943,793,171   139,725,795    591,378,698,544
  201   2014/04 171,744,486  159,813,411,760   143,446,790    621,015,432,437
  202   2014/06 173,353,076  161,822,845,643   175,779,064    719,581,958,743
  203   2014/08 174,108,750  165,722,980,375   189,080,419    774,052,098,731
  204   2014/10 178,322,253  181,563,676,918   196,049,974    805,549,167,708
  205   2014/12 179,295,769  184,938,063,614   200,301,550    848,977,922,022
  206   2015/02 181,336,445  187,893,826,750   205,465,046    873,281,414,087
  207   2015/04 182,188,746  189,739,230,107   243,779,199    969,102,906,813
  208   2015/06 185,019,352  193,921,042,946   258,702,138  1,038,937,210,221
  209   2015/08 187,066,846  199,823,644,287   302,955,543  1,163,275,601,001
  210   2015/10 188,372,017  202,237,081,559   309,198,943  1,222,635,267,498
  211   2015/12 189,232,925  203,939,111,071   317,122,157  1,297,865,618,365
  212   2016/02 190,250,235  207,018,196,067   333,012,760  1,399,865,495,608
  213   2016/04 193,739,511  211,423,912,047   338,922,537  1,452,207,704,949
  214   2016/06 194,463,572  213,200,907,819   350,278,081  1,556,175,944,648
  215   2016/08 196,120,831  217,971,437,647   359,796,497  1,637,224,970,324
  216   2016/10 197,390,691  220,731,315,250   363,213,315  1,676,238,489,250
  217   2016/12 198,565,475  224,973,060,433   395,301,176  1,817,189,565,845
  218   2017/02 199,341,377  228,719,437,638   409,490,397  1,892,966,308,635
  219   2017/04 200,877,884  231,824,951,552   451,840,147  2,035,032,639,807
  220   2017/06 201,663,568  234,997,362,623   487,891,767  2,164,683,993,369
  221   2017/08 203,180,606  240,343,378,259   499,965,722  2,242,294,609,510
  222   2017/10 203,953,682  244,914,705,468   508,825,331  2,318,156,361,999
  223   2017/12 206,293,625  249,722,163,594   551,063,065  2,466,098,053,327
  224   2018/02 207,040,555  253,630,708,098   564,286,852  2,608,532,210,351
  225   2018/04 208,452,303  260,189,141,631   621,379,029  2,784,740,996,536
  226   2018/06 209,775,348  263,957,884,539   639,804,105  2,944,617,324,086
  227   2018/08 208,831,050  260,806,936,411   665,309,765  3,204,855,013,281
  228   2018/10 209,656,636  279,668,290,132   722,438,528  3,444,172,142,207
  229   2018/12 211,281,415  285,688,542,186   773,773,190  3,656,719,423,096
  230   2019/02 212,260,377  303,709,510,632   945,019,312  4,164,513,961,679
  231   2019/04 212,775,414  321,680,566,570   993,732,214  4,421,986,382,065
  232   2019/06 213,383,758  329,835,282,370 1,022,913,321  4,847,677,297,950
  233   2019/08 213,865,349  366,733,917,629 1,075,272,215  5,585,922,333,160
  234   2019/10 216,763,706  386,197,018,538 1,097,629,174  5,985,250,251,028
  235   2019/12 215,333,020  388,417,258,009 1,127,023,870  6,277,551,200,690
  236   2020/02 216,214,215  399,376,854,872 1,206,720,688  6,968,991,265,752
  237   2020/04 216,531,829  415,770,027,949 1,267,547,429  7,788,133,221,338
  238   2020/06 217,122,233  427,823,258,901 1,302,852,615  8,114,046,262,158
  239   2020/08 218,642,238  654,057,069,549 1,408,122,887  8,841,649,410,652
  240   2020/10 219,055,207  698,688,094,046 1,432,874,252  9,215,815,569,509
  241   2020/12 221,467,827  723,003,822,007 1,517,995,689 11,830,842,428,018
  242   2021/02 226,241,476  776,291,211,106 1,563,938,043 12,270,717,209,612
  243   2021/04 227,123,201  832,400,799,511 1,590,670,459 12,732,048,052,023
  244   2021/06 227,888,889  866,009,790,959 1,632,796,606 13,442,974,346,437


EMBL

Release Date          Entries           Residues
------------------------------------------------
    1   1982/03           568            585,433
    2   1983/04           811          1,114,447
    3   1983/12         1,481          1,654,854
    4   1984/08         1,698          2,147,205
    5   1985/04         2,378          2,874,493
    6   1985/08         4,835          4,567,592
    7   1985/12         5,789          5,622,638
    8   1986/04         6,395          6,353,040
    9   1986/09         7,630          7,813,214
   10   1986/12         8,817          9,766,948
   11   1987/04        11,621         12,189,783
   12   1987/07        12,706         13,638,061
   13   1987/10        14,397         16,023,442
   14   1988/01        15,344         17,272,160
   15   1988/05        17,961         20,318,442
   16   1988/08        19,592         22,625,941
   17   1988/11        20,695         24,211,054
   18   1989/02        22,938         27,249,830
   19   1989/05        24,365         29,066,676
   20   1989/08        26,223         31,240,948
   21   1989/11        28,679         34,748,087
   22   1990/02        31,508         38,165,786
   23   1990/05        34,902         42,923,803
   24   1990/08        37,784         47,354,438
   25   1990/11        41,580         52,900,354
   26   1991/02        43,745         55,859,549
   27   1991/05        46,871         59,915,244
   28   1991/09        54,558         70,448,052
   29   1991/12        57,765         75,400,487
   30   1992/02        63,378         83,574,342
   31   1992/06        72,481         94,390,065
   32   1992/08        79,377        101,292,310
   33   1992/12        89,100        111,413,979
   34   1993/03        99,591        121,420,828
   35   1993/06       115,726        139,235,246
   36   1993/09       133,252        149,509,542
   37   1993/12       154,111        163,353,378
   38   1994/03       171,787        179,346,566
   39   1994/06       185,883        193,147,264
   40   1994/09       212,744        212,015,482
   41   1994/12       234,501        227,275,187
   42   1995/03       309,892        265,066,849
   43   1995/06       422,829        316,126,328
   44   1995/09       509,167        363,589,514
   45   1995/12       625,746        427,968,276
   46   1996/03       704,411        474,040,426
   47   1996/06       830,484        551,090,714
   48   1996/08       931,582        609,302,252
   49   1996/12     1,051,273        696,560,088
   50   1997/03     1,191,742        790,157,975
   51   1997/05     1,223,674        815,336,041
   52   1997/10     1,787,004      1,181,167,498
   53   1997/12     1,795,035      1,200,204,361
   54   1998/03     2,125,225      1,427,634,373
   55   1998/06     2,131,533      1,434,776,497
   56   1998/10     2,689,618      1,904,091,473
   57   1998/12     3,046,471      2,164,718,256
   58   1999/03     3,272,064      2,355,200,790
   59   1999/06     3,952,878      2,924,568,545
   60   1999/09     4,719,266      3,541,783,272
   61   1999/12     5,303,436      4,508,169,737
   62   2000/03     5,865,742      6,120,908,677
   63   2000/06     6,760,113      8,255,674,441
   64   2000/09     8,344,436      9,650,223,037
   65   2000/12     9,549,382     10,710,321,435
   66   2001/03    11,169,673     11,916,112,872
   67   2001/06    12,044,420     12,821,742,622
   68   2001/09    12,964,797     13,727,100,206
   69   2001/12    14,366,182     14,593,887,845
   70   2002/03    15,851,373     17,807,926,047
   71   2002/06    17,226,421     20,017,246,707
   72   2002/09    18,324,246     22,814,535,107
   73   2002/12    20,857,746     27,451,572,799
   74   2003/03    23,234,788     29,700,171,231
   75   2003/06    25,214,767     32,195,012,823
   76   2003/09    27,248,475     33,885,908,155
   77   2003/12    30,351,263     36,042,464,651
   78   2004/03    32,631,252     37,984,728,579
   79   2004/06    39,214,123     65,185,548,741  WGS added
   80   2004/09    42,312,264     70,222,432,184
   81   2004/12    46,105,397     79,271,300,840
   82   2005/03    49,474,402     85,134,714,382
   83   2005/06    54,491,598     94,996,164,558
   84   2005/09    58,758,902    107,562,580,723
   85   2005/12    64,739,883    116,106,677,726
   86   2006/03    69,783,593    126,401,347,060
   87   2006/06    74,034,622    134,602,904,495
   88   2006/09    80,591,891    146,595,277,574
   89   2006/12    83,666,567    150,163,403,742
   90   2007/03    87,475,506    159,925,050,518
   91   2007/06    97,361,640    170,766,876,848
   92   2007/09   105,696,243    198,879,188,987
   93   2007/12   109,626,755    207,453,283,380
   94   2008/03   114,475,051    215,540,553,360
   95   2008/06   131,771,254    224,351,474,408
   96   2008/09   137,951,674    235,135,312,382
   97   2008/12   150,911,591    259,647,155,718
   98   2009/01   155,114,144    265,307,725,081
   99   2009/03   158,001,051    270,341,262,540
  100   2009/06   161,580,181    275,798,912,115
  101   2009/09   163,656,234    283,748,816,763
  102   2009/12   167,493,839    266,361,987,641
  103   2010/03   185,231,366    281,478,752,483
  104   2010/06   190,119,871    287,946,554,761
  105   2010/09   195,241,608    292,078,866,691
  106   2010/12   199,720,869    301,835,769,489
  107   2011/03   206,571,716    319,689,980,026
  108   2011/06   212,904,159    326,991,023,050
  109   2011/09   220,504,007    346,598,699,035
  110   2011/12   230,021,806    376,471,768,435
  111   2012/03   241,636,507    410,745,134,662
  112   2012/06   247,335,689    429,512,389,024
  113   2012/09   252,106,363    450,481,663,919
  114   2012/12   266,255,715    499,882,374,645
  115   2013/03   282,265,591    544,558,960,111
  116   2013/06   309,513,621    616,248,681,624
  117   2013/09   324,201,244    670,004,320,378
  118   2013/12   332,944,272    714,448,074,322
  119   2014/03   393,460,058    783,467,257,469
  120   2014/06   441,582,575    883,726,016,221
  121   2014/09   469,991,586    997,958,152,853
  122   2014/12   510,014,239  1,094,969,877,589
  123   2015/03   532,718,175  1,154,095,724,206
  124   2015/06   608,493,388  1,326,648,168,352
  125   2015/09   629,681,877  1,401,669,271,501
  126   2015/12   668,347,471  1,496,520,157,048
  127   2016/03   724,619,242  1,627,691,638,946
  128   2016/06   742,621,853  1,743,853,810,150
  129   2016/09   760,132,842  1,857,001,280,626
  130   2016/12   777,890,228  1,932,514,942,067
  131   2017/03   803,147,518  2,044,465,860,905
  132   2017/06   838,955,095  2,209,428,677,754
  133   2017/09   869,775,341  2,329,476,775,417
  134   2017/11 1,157,925,701  2,700,988,919,811
  135   2018/03   249,139,351    250,505,346,447  WGS and TSA removed
  136   2018/06   250,449,309    257,903,931,495
  137   2018/09   253,432,917    284,014,423,756
  138   2018/11   255,215,657    288,713,594,828
  139   2019/03 2,217,365,678  5,533,038,671,846  WGS and TSA included
  140   2019/06   261,149,873    339,264,788,161  WGS and TSA removed
  141   2019/09   260,968,673    369,883,136,884
  142   2019/12   262,294,587    387,071,790,478
  143   2020/03   263,421,789    408,005,271,872  Last ENA quarterly release


PIR

Release Date       Entries       Residues
-----------------------------------------
        1982/10      1,993        330,893  NBRF Protein Sequence Database
        1983/02      2,145        363,573
        1983/06      2,222        387,600
        1983/08      2,372        430,262
        1983/11      2,509        469,942
        1984/01      2,511        470,158
        1984/02      2,598        500,581
    1   1984/04      2,676        526,466  PIR first release
    2   1984/08      2,784        557,759
    3   1984/11      2,898        591,717
    4   1985/02      3,061        657,289
    5   1985/05      3,182        694,014
    6   1985/08      3,309        738,997
    7   1985/11      3,447        778,218
    8   1986/02      3,860        883,800  PIR2 added
    9   1986/05      3,993        944,429
   10   1986/08      4,248        962,996
   11   1986/12      4,612      1,062,149
   12   1987/03      4,750      1,103,446
   13   1987/06      5,415      1,302,966
   14   1987/09      6,418      1,574,608
   15   1987/12      6,796      1,684,561
   16   1988/03      7,240      1,855,982
   17   1988/06      8,588      2,209,397
   18   1988/09      9,138      2,377,999
   19   1988/12     10,527      2,802,055
   20   1989/03     11,158      3,002,182
   21   1989/06     12,476      3,406,022
   22   1989/09     13,413      3,707,414
   23   1989/12     14,372      3,977,903
   24   1990/03     16,524      4,627,393
   25   1990/06     17,731      4,999,063
   26   1990/09     25,814      7,348,950  PIR3 added
   27   1990/12     26,798      7,620,668
   28   1991/03     28,232      8,076,497
   29   1991/06     31,895      9,091,049
   30   1991/09     33,989      9,697,617
   31   1991/12     36,150     10,360,161
   32   1992/03     40,298     11,831,134
   33   1992/06     42,215     12,411,076
   34   1992/09     44,900     13,205,577
   35   1992/12     47,234     13,875,840
   36   1993/03     52,257     15,485,766
   37   1993/06     56,849     16,691,590
   38   1993/09     61,248     18,022,824
   39   1993/12     64,760     19,009,044
   40   1994/03     67,423     19,747,297
   41   1994/06     70,848     20,811,057
   42   1994/09     71,995     21,244,777
   43   1994/12     75,511     22,468,834
   44   1995/03     77,573     23,340,141
   45   1995/06     78,488     23,849,247
   46   1995/09     82,361     25,276,988
   47   1995/12     82,130     25,426,960
   48   1996/03     82,182     25,727,516
   49   1996/06     84,169     26,719,547
   50   1996/09     89,912     28,507,787
   51   1996/12     91,006     28,888,923
   52   1997/03     92,175     29,420,590
   53   1997/06     95,051     30,469,580
   54   1997/09     98,250     31,625,275
   55   1997/12    105,998     33,852,246
   56   1998/03    107,076     34,162,168
   57   1998/06    109,075     34,838,376
   58   1998/09    116,738     37,483,768
   59   1998/12    117,704     37,913,700
   60   1999/03    122,810     40,089,044
   61   1999/06    130,886     43,065,574
   62   1999/09    142,080     47,193,853
   63   1999/12    168,808     58,654,532
   64   2000/03    178,050     61,909,674
   65   2000/06    182,106     63,485,053
   66   2000/09    195,891     67,925,498
   67   2000/12    198,801     68,747,441
   68   2001/03    219,241     76,199,051
   69   2001/06    232,624     80,607,033
   70   2001/09    250,417     85,926,567
   71   2001/12    274,514     93,455,518
   72   2002/04    283,175     96,096,690
   73   2002/06    283,239     96,144,196
   74   2002/09    283,227     96,130,023
   75   2003/01    283,268     96,147,517
   76   2003/03    283,308     96,164,110
   77   2003/06    283,329     96,171,031
   78   2003/10    283,366     96,186,963
   79   2004/03    283,367     96,187,020
   80   2004/12    283,416     96,216,763  PIR final release


PRF

Release Date       Entries       Residues
-----------------------------------------
   HE   1983/05      1,189        129,350
    P   1983/09      2,597        328,302
    S   1984/01      3,349        508,268
    T   1984/05      3,853        638,579
    U   1984/09      4,591        820,929
    V   1985/01      5,258        977,841
    W   1985/05      6,122      1,160,990
    X   1985/09      6,915      1,356,648
    Y   1986/01      7,687      1,565,240
    Z   1986/05      8,447      1,780,235
    A   1986/09      9,123      1,988,548
    B   1987/01      9,888      2,196,866
    C   1987/05     10,021      2,351,308
    D   1987/09     10,738      2,583,047
    F   1988/01     11,414      2,812,137
    G   1988/03     11,766      2,933,233
    I   1988/06     12,825      3,296,592
    K   1988/09     14,234      3,777,160
    M   1989/01     15,586      4,267,675
    O   1989/05     16,969      4,763,710
    R   1989/09     18,383      5,247,659
90-01   1990/01     20,206      5,944,750
90-05   1990/05     22,201      6,674,591
90-09   1990/09     24,716      7,596,021
91-01   1991/01     26,758      8,360,579
91-05   1991/05     28,552      9,026,117
91-09   1991/09     30,471      9,707,717
92-01   1992/01     33,109     10,701,989
92-05   1992/05     35,069     11,438,479
92-09   1992/09     37,431     12,338,141
93-01   1993/01     39,041     12,942,745
93-03   1993/03     40,493     13,450,986
93-05   1993/05     41,784     13,933,155
93-07   1993/07     43,396     14,540,060
93-09   1993/09     45,323     15,229,031
93-11   1993/11     47,895     16,163,279
94-01   1994/01     49,109     16,615,985
94-03   1994/03     50,427     17,115,256
94-05   1994/05     52,424     17,878,290
94-07   1994/07     54,336     18,618,956
94-09   1994/09     55,686     19,113,900
94-11   1994/11     57,526     19,781,002
95-03   1995/03     60,280     20,878,197
95-05   1995/05     61,976     21,586,557
95-07   1995/07     64,224     22,462,626
95-09   1995/09     66,088     23,199,573
95-11   1995/11     68,344     24,039,370
96-05   1996/05     73,507     26,117,830
96-07   1996/07     75,002     26,744,498
96-09   1996/09     76,516     27,346,797
96-11   1996/11     78,074     27,986,179
97-01   1997/01     80,057     28,814,925
97-03   1997/03     81,745     29,523,962
97-05   1997/05     83,654     30,172,232
97-07   1997/07     85,455     30,915,028
97-09   1997/09     87,210     31,626,928
97-11   1997/11     89,650     32,564,615
98-01   1998/01     92,780     33,698,792
98-03   1998/03     98,089     35,346,668
98-05   1998/05    101,648     36,591,984
98-07   1998/07    103,558     37,415,707
98-09   1998/09    108,435     39,113,650
98-11   1998/11    110,607     40,088,986
99-01   1999/01    112,325     40,777,760
99-03   1999/03    114,700     41,714,944
99-05   1999/05    116,101     42,247,911
99-07   1999/07    118,187     43,138,973
99-09   1999/09    121,124     44,331,510
99-11   1999/11    127,987     46,538,259
   71   2000/01    131,333     47,773,661
   72   2000/03    133,212     48,514,385
   75   2000/09    141,245     51,691,661
   76   2000/11    143,874     52,686,062
   77   2001/01    148,099     54,132,882
   78   2001/03    156,099     56,871,020
   79   2001/05    159,365     58,171,975
   80   2001/07    167,028     60,637,099
   81   2001/09    177,941     64,250,697
   82   2001/11    184,903     66,779,062
   83   2002/01    192,393     69,036,232
   84   2002/03    195,660     70,303,230
   85   2002/05    201,504     72,366,792
   86   2002/07    205,029     73,676,338
   87   2002/09    210,905     75,522,558
   88   2002/11    213,858     76,589,039
   89   2003/01    216,752     77,654,078
   90   2003/03    225,081     80,471,112
   91   2003/05    229,482     81,948,043
   92   2003/07    233,109     83,159,165
   93   2003/09    236,775     84,291,559
   94   2003/11    239,691     85,242,614
   96   2004/03    250,321     88,775,826
   97   2004/06    256,940     91,047,656
   98   2004/08    262,644     93,071,449
   99   2004/09    270,439     95,679,062
  101   2005/01    308,406    107,781,252
  102   2005/04    353,698    122,815,546
  103   2005/06    381,094    133,018,204
  104   2005/07    422,024    148,104,854
  105   2005/09    459,765    164,142,730
  106   2005/11    476,919    169,820,614
  108   2006/03    555,007    195,757,276
  110   2006/07    632,307    218,934,604
  111   2006/09    656,550    225,703,601
  113   2007/01    773,622    262,958,213
  114   2007/03    791,254    268,734,103
  115   2007/05    810,251    274,837,576
  116   2007/07    832,123    281,306,426
  117   2007/09    856,684    288,910,758
  118   2007/11    884,108    297,506,754
  119   2008/01    898,996    301,975,793
  120   2008/03    917,732    308,121,247
  121   2008/05    964,264    319,975,640
  122   2008/07    985,606    326,208,855
  123   2008/09  1,010,213    334,346,452
  124   2008/11  1,040,207    343,704,089
  125   2009/01  1,058,034    349,200,569
  126   2009/03  1,093,029    362,083,599
  127   2009/05  1,141,626    377,716,090
  128   2009/07  1,202,938    396,565,000
  129   2009/09  1,237,647    408,230,417
  130   2009/11  1,277,847    421,621,904
  131   2010/01  1,326,246    436,826,311
  132   2010/03  1,365,912    448,959,615  PRF final release


SWISS-PROT

Release Date       Entries       Residues
-----------------------------------------
    2   1986/09      3,939        900,163
    3   1986/11      4,160        969,641
    4   1987/04      4,387      1,036,010
    5   1987/09      5,205      1,327,683
    6   1988/01      6,102      1,653,982
    7   1988/04      6,821      1,885,771
    8   1988/08      7,724      2,224,465
    9   1988/11      8,702      2,498,140
   10   1989/03     10,008      2,952,613
   11   1989/07     10,856      3,265,966
   12   1989/10     12,305      3,797,482
   13   1990/01     13,837      4,347,336
   14   1990/04     15,409      4,914,264
   15   1990/08     16,941      5,486,399
   16   1990/11     18,364      5,986,949
   17   1991/02     20,024      6,524,504
   18   1991/05     20,772      6,792,034
   19   1991/08     21,795      7,173,785
   20   1991/11     22,654      7,500,130
   21   1992/03     23,742      7,866,596
   22   1992/05     25,044      8,375,696
   23   1992/08     26,706      9,011,391
   24   1992/12     28,154      9,545,427
   25   1993/04     29,955     10,214,020
   26   1993/07     31,808     10,875,091
   27   1993/10     33,329     11,484,420
   28   1994/02     36,000     12,496,420
   29   1994/06     38,303     13,464,008
   30   1994/10     40,292     14,147,368
   31   1995/02     43,470     15,335,248
   32   1995/11     49,340     17,385,503
   33   1996/02     52,205     18,531,385
   34   1996/10     59,021     21,210,388
   35   1997/11     69,113     25,083,768
   36   1998/07     74,019     26,840,295
   37   1998/12     77,977     28,268,293
   38   1999/07     80,000     29,085,965
   39   2000/05     86,593     31,411,157
   40   2001/10    101,602     37,315,215
   41   2003/02    122,564     44,986,459
   42   2003/10    135,850     50,046,799
   43   2004/03    146,720     54,093,154
   44   2004/07    153,871     56,608,159
   45   2004/10    163,235     59,631,787
   46   2005/02    168,297     61,443,278
   47   2005/05    181,577     65,746,672
   48   2005/09    194,317     70,391,852
   49   2006/02    207,132     75,438,310
   50   2006/05    222,289     81,585,146
   51   2006/10    241,242     88,541,632
   52   2007/03    261,513     95,638,062
   53   2007/05    269,293     98,902,758
   54   2007/07    276,256    101,466,206
   55   2008/02    356,194    127,836,513
   56   2008/07    392,667    141,217,034
   57   2009/03    428,650    154,416,236
2010_06 2010/06    517,100    182,146,551
2010_12 2010/02    523,151    184,678,199
2011_06 2011/06    529,056    187,423,367
2011_12 2011/02    533,657    189,261,966
2012_06 2012/06    536,489    190,389,898
2013_04 2013/04    539,829    191,670,831
2013_12 2013/02    541,954    192,668,437
2014_05 2014/05    545,388    193,948,795
2014_08 2014/08    546,238    194,363,168
2014_11 2014/01    547,085    194,742,747
2015_11 2015/01    549,832    196,078,138
2016_02 2016/02    550,552    196,472,675
2016_11 2016/01    553,231    197,953,409
2017_03 2017/03    553,941    198,311,666
2017_07 2017/07    555,100    198,754,198
2018_01 2018/01    556,568    199,530,821
2018_04 2018/04    557,275    199,856,860
2018_08 2018/08    558,125    200,328,830
2018_11 2018/01    558,898    200,750,628
2019_02 2019/02    559,228    200,905,869
2019_05 2019/05    560,292    201,357,942
2019_10 2019/00    561,356    201,858,328
2020_01 2020/01    561,911    202,173,710
2021_01 2021/01    564,277    203,340,877


KEGG GENES

Release Date       Entries
--------------------------
    7   1998/07     65,592
    8   1998/10     76,891
    9   1999/01     78,337
   10   1999/04     97,480
   11   1999/07     93,445
   11.1 1999/09    107,118
   12   1999/10    110,586                         (Genome)
   13   2000/01    114,553                            25
   14   2000/04    129,057                            30
   15   2000/07    138,518                            31
   16   2000/10    157,339                            34
   17   2001/01    174,226                            39
   18   2001/04    203,246                            45
   19   2001/07    223,104                            53
   20   2001/10    248,705                            60
   21   2002/01    328,344                            79
   22   2002/04    340,353                            82
   23   2002/07    343,860                (KO)        95
   24   2002/10    358,597                3,115      101
   25   2003/01    417,535                3,371      118
   26   2003/04    486,190                3,444      133
   27   2003/07    526,464                3,627      145
   28   2003/10    580,843    (DGENES)    3,828      163
   29   2004/01    597,435    301,883     3,976      174
   30   2004/04    659,611    299,559     4,425      190
   31   2004/07    713,034    285,449     4,715      205
   32   2004/10    772,389    339,558     5,540      220
   33   2005/01    866,039    438,613     5,841      233
   34   2005/04    911,578    412,624     6,220      247
   35   2005/07    940,517    597,269     6,674      284
   36   2005/10  1,133,099    597,849     7,499      313
   37   2006/01  1,254,322                7,983      348
   38   2006/04  1,408,931    597,092     8,254      374
   39   2006/07  1,549,332    589,268     8,553      409
   40   2006/10  1,646,611                8,942      436
   41   2007/01  1,871,732                9,286      486
   42   2007/04  2,038,004                9,770      536
   43   2007/07  2,396,769    608,087    10,016      593
   44   2007/10  2,669,491    286,440    10,325      650
   45   2008/01  2,846,561    379,373    10,686      694
   46   2008/04  3,019,823    542,031    10,763      748
   47   2008/07  3,321,599    530,515    10,958      806
   48   2008/10  4,010,399  <= merged    11,208      857
   49   2009/01  4,214,060  <= merged    11,417      899
   50   2009/04  4,229,488    239,041    11,760      957
   51   2009/07  4,604,914    151,662    12,259    1,022
   52   2009/10  4,854,460               12,520    1,088
   53   2010/01  5,195,943    146,715    12,877    1,151
   54   2010/04  5,422,765    232,640    13,369    1,209
   55   2010/07  5,659,677    294,638    13,660    1,263
   56   2010/10  5,818,226               13,820    1,329
   57   2011/01  6,104,532    372,418    14,069    1,390
   58   2011/04  6,375,680               14,387    1,463
   59   2011/07  6,759,505    398,519    14,857    1,573
   60   2011/10  7,107,929    365,986    15,200    1,639
   61   2012/01  7,176,414    356,803    15,400    1,663
   62   2012/04  7,674,147               15,552    1,781
   63   2012/07  8,837,513               15,728    2,168
   64   2012/10  9,113,391    335,886    15,950    2,262
   65   2013/01  9,794,752               16,282    2,407
   66   2013/04 10,211,206    288,761    16,485    2,535
   67   2013/07 10,909,953    432,488    16,791    2,720
   68   2013/10 11,509,872    417,865    17,172    2,867
   69   2014/01 12,216,183    442,323    17,399    2,986
   70   2014/04 12,472,984    514,175    17,679    2,999
   71   2014/07 13,149,919    573,961    17,907    3,114
   72   2014/10 14,273,877    617,111    18,088    3,321
   73   2015/01 15,346,261    654,883    18,348    3,521
   74   2015/04 16,400,093               18,551    3,738
   75   2015/07 17,427,876    602,101    18,814    3,961
   76   2015/10 17,774,331               18,969    4,064
   77   2016/01 17,956,002               19,214    4,086
   78   2016/04 18,763,015               19,365    4,185 (Virus)
   79   2016/07 19,363,974               19,717    4,315 + 120
   80   2016/10 20,221,454  discontinued 20,140    4,447 + 317
   81   2017/01 20,700,605               20,420    4,567 + 317
   82   2017/04 21,832,008               20,775    4,748 + 317
   83   2017/07 22,754,774               21,188    4,900 + 317
   84   2017/10 24,190,025               21,549    5,064 + 317
   85   2018/01 25,228,902               21,712    5,213 + 317
   86   2018/04 26,069,447               21,915    5,344 + 317
   87   2018/07 26,598,248               22,170    5,480 + 317
   88   2018/10 27,340,623               22,290    5,615 + 328
   89   2019/01 27,716,784               22,456    5,718 + 328
   90   2019/04 28,826,174               22,639    5,862 + 328
   91   2019/07 29,616,625               22,853    5,994 + 338
   92   2019/10 30,038,178               23,085    6,149 + 338
   93   2020/01 30,679,211               23,187    6,305 + 340
   94   2020/04 31,259,359               23,290    6,461 + 341
   95   2020/07 31,896,414               23,424    6,626 + 341
   96   2020/10 32,622,738               23,568    6,782 + 349
   97   2021/01 33,189,781               23,923    6,927 + 349
   98   2021/04 33,848,488               24,210    7,086 + 349
   99   2021/07 34,901,462               24,465    7,254 + 355


PDB

Release Date       Entries
--------------------------
    5   1977/11         84
    6   1978/05         96
    7   1978/12        112
    8   1979/04        123
    9   1979/07        126
   10   1979/10        134
   13   1980/07        146
   14   1980/10        151
   15   1981/01        153
   16   1981/04        159
   17   1981/07        167
   18   1981/10        172
   19   1982/01        172
   20   1982/04        190
   21   1982/07        210
   22   1982/10        215
   23   1983/01        220
   24   1983/04        224
   25   1983/07        230
   26   1983/10        234
   27   1984/01        243
   28   1984/04        237
   29   1984/07        252
   30   1984/10        254
   31   1985/01        264
   32   1985/04        270
   33   1985/07        273
   34   1985/10        279
   35   1986/01        286
   36   1986/04        288
   37   1986/07        294
   38   1986/10        296
   39   1987/01        301
   40   1987/04        307
   41   1987/07        310
   42   1987/10        318
   43   1988/01        328
   44   1988/04        354
   45   1988/07        368
   46   1988/10        381
   47   1989/01        413
   48   1989/04        427
   49   1989/07        435
   50   1989/10        459
   51   1990/01        503
   52   1990/04        535
   53   1990/07        554
   54   1990/10        597
   55   1991/01        622
   56   1991/04        655
   57   1991/07        688
   58   1991/10        790
   59   1992/01        851
   60   1992/04      1,005
   61   1992/07      1,146
   62   1992/10      1,307
   63   1993/01      1,492
   64   1993/04      1,666
   65   1993/07        ??? (not distributed)
   66   1993/10      2,049
   67   1994/01      2,327
   68   1994/04      2,440
   69   1994/07      2,684
   70   1994/10      2,921        901,772
   71   1995/01      3,091        926,235
   72   1995/04      3,528      1,069,045
   73   1995/07      3,765      1,144,986
   74   1995/10      3,897      1,191,278
   75   1996/01      4,238      1,317,176
   76   1996/04      4,508      1,403,823
   77   1996/07      4,728      1,479,089
   78   1996/10      4,949      1,552,150
   79   1997/01      5,478      1,756,248
   80   1997/04      5,887      1,912,201
   81   1997/07      6,173      2,023,537
   82   1997/10      6,567      2,207,715
   83   1998/01      7,023      2,417,274
   84   1998/04      7,533      2,644,523
   85   1998/07      8,035
   86   1998/10      8,492      3,158,591
    1   1999/03      9,176                 PDB moved to RCSB
    2   1999/06      9,631
    3   1999/09     10,213
    4   1999/12     11,317
    5   2000/04     12,110
    6   2000/07     12,592
    7   2000/10     13,270
    8   2001/01     14,040
    9   2001/04     14,731
   10   2001/07     15,488
   11   2001/10     16,121
   12   2002/01     16,972
   13   2002/04     17,737
   14   2002/07     18,528
   15   2002/10     18,838
   16   2003/01     19,623
   17   2003/04     20,533
   18   2003/06     21,248
   19   2003/10     22,700
   20   2004/01     23,792
   21   2004/04     24,908
   22   2004/07     26,144
   23   2004/10     27,428
   24   2005/01     28,992
   25   2005/04     30,263
   26   2005/07     31,535
   27   2005/10     32,823
   28   2006/01     34,376
   29   2006/04     35,813
   30   2006/07     37,392
   31   2006/10     39,051
   32   2007/01     40,933
   33   2007/04     42,474
   34   2007/07     44,320
   35   2007/10     46,051
   36   2008/01     48,091
   37   2008/04     49,760
   38   2008/07     51,491
   39   2008/10     53,384
   40   2009/01     55,072
   41   2009/04     56,751
   42   2009/07     58,588
   43   2009/10     60,464
   44   2010/01     62,388
   45   2010/04     64,357
   46   2010/07     66,212
   47   2010/10     68,288
   48   2011/01     70,231
   49   2011/04     72,104
   50   2011/07     74,140
   51   2011/10     76,132
   52   2012/01     78,237
   53   2012/04     80,402
   54   2012/07     82,679
   55   2012/10     84,846
   56   2013/01     87,153
   57   2013/04     89,212
   58   2013/07     91,761
   59   2013/10     94,143
   60   2014/01     96,692
   61   2014/04     99,122
   62   2014/07    101,397
   63   2014/10    103,735
   64   2015/01    105,465
   65   2015/04    107,754
   66   2015/07    110,071
   67   2015/10    112,561
   68   2016/01    114,697
   69   2016/04    117,438
   70   2016/07    120,057
   71   2016/10    123,021
   72   2017/01    125,463
   73   2017/04    128,783
   74   2017/07    131,484
   75   2017/10    133,920
   76   2018/01    136,472
   77   2018/04    139,026
   78   2018/07    141,616
   79   2018/10    144,682
   80   2019/01    147,610
   81   2019/04    150,393
   82   2019/07    153,328
   83   2019/10    156,365
   84   2020/01    159,140
   85   2020/04    162,269
   86   2020/07    165,956
   87   2020/10    169,436
   88   2021/01    173,005
   89   2021/04    176,247


Text last updated: July 1, 2021
Figure last updated: July 1, 2021

Kanehisa Laboratories Pathway Solutions Bioinfomatics Center