Date |
September 13, 2004 |
Speaker |
Dr. Tadashi Kadowaki, Laboratory of Genomic Drug Discovery Science, Graduate School of Pharmaceutical Sciences, Kyoto University |
Title |
Finding splicing variants by gene expression data |
Abstract |
Alternative splicing is a major source of diversity in mammalian
proteins. Actual information is derived from aligning sequences in
the public database, but it is not enough to analyze mechanisms about
alternative splicing events. Recent development of the microarray technology
helps us to focus on expression levels of each axon in a gene. Expression
data has an advantage over sequence data, because it contains information
about co-expressed genes that control alternative splicing events.
However, the current splicing variant analysis requires custom-made
microarray platforms. We developed a method to detect
splicing variants from publicly available gene expression data for
offering information about alternative splicing events with co-expressed
genes. |
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