Abstract |
Highly parallel experimental biology is offering opportunities
to not just accomplish work more easily, but to explore for underlying
governing principles.&&Recent analysis of the large-scale
organization of gene expression has revealed its complex and dynamic
nature.&&However, the underlying dynamics that generate complex
gene expression and cellular organization are not yet understood.&&To
comprehensively and quantitatively elucidate these underlying gene
expression dynamics, we have analyzed genome-wide gene expression
in many experimental conditions in Escherichia coli, Saccharomyces
cerevisiae, Arabidopsis thaliana, Drosophila melanogaster, Mus musculus
and Homo sapiens.&&Here we demonstrate that the gene expression
dynamics follows the same and surprisingly simple principle from
Escherichia coli to man; where gene expression changes are proportional
to their expression levels, and show that this 'proportional' dynamics
or 'rich-travel-more' mechanism can regenerate the observed complex
and dynamic organization of the transcriptome. These findings provide
a universal principle in the regulation of gene expression, show
how complex and dynamic organization can emerge from simple underlying
dynamics, and demonstrate the flexibility of transcription across
a< wide range of expression levels.&&We will also discuss
about the "rich-travel-more" mechanism in the evolution
of heterogeneous organization of metabolic networks. |