Ministry of Education, Science and Culture, Japan
Human Genome Program
List of Investigators
FY 1995
Grant-in-Aid for Creative Basic Research
"Human Genome Analysis"
Principal Investigator
Kenichi Matsubara Professor, Director, Institute for Molecular and Cellular Biology, Osaka University
A0. Coordination Committee
Asao Fujiyama Associate Professor, National Institute of Genetics
Takashi Gojobori Professor, Director, Center for Information Biology, National Institute of Genetics
Katsuyuki Hashimoto Chief, Division of Genetic Resources, National Institute of Health
Kazushige Hirosawa Professor, Director, Institute of Medical Science, The University of Tokyo
Tada-aki Hori Director, Genome Reserch Group, National Institute of Radiological Sciences
Yoji Ikawa Professor, Tokyo Medical and Dental University
Akira Ishihama Professor, National Institute of Genetics
Minoru Kanehisa Professor, Kyoto University
Kenichi Matsubara Professor, Director, Institute for Molecular and Cellular Biology, Osaka University
Yuzou Minobe Director, Department of Molecular Biology, National Institute of Agrobiological Resources, MAFF
Shiro Miwa Director, Okinaka Memorial Institute for Medical Research
Masami Muramatsu Professor, Saitama Medical School
Keiko Nakamura Deputy Director-General, Biohistory Research Hall
Yusuke Nakamura Professor, The University of Tokyo
Shigetada Nakanishi Professor, Kyoto University
Susumu Nishimura Senior Executive Director, Banyu Tsukuba Research Institute
Misao Ohki Chief, Radiobiology Division, National Cancer Center Research Institute
Hiroto Okayama Professor, The University of Tokyo
Yoshiyuki Sakaki Professor, The University of Tokyo
Haruo Sugano Director Emeritus, Japanese Foundation for Cancer Reserch
Nobutaka Takahashi Director Plant Homeostasis Group, Frontier Research Program, Instisute of Physical and Chemical Research (RIKEN)
Fumimaro Takaku President, International Medical Center of Japan
Mituru Takanami Director, Kazusa DNA Research Institute
Masaaki Terada Director, National Cancer Center Research Institute
Jun-ichi Tomizawa Director-General, National Institute of Genetics
Kumao Toyoshima President, The Center for Adult Diseases, Osaka
Mitsuaki Yoshida Professor, The University of Tokyo
Hiroshi Yoshikawa Professor, Dean, Nara Institute of Science and Technology
A1. Project Team 1: Physical and Genetical Analysis
Asao Fujiyama Associate Professor, National Institute of Genetics
Kenshi Hayashi Professor, Kyushu University
Takashi Imai Senior Resercher, National Institute of Radiological Sciences
Hidetoshi Inoko Professor, Tokai University School of Medicine
Fuyuki Ishikawa Associate Professor, Tokyo Institute of Technology
Masaharu Isobe Associate Professor, Toyama University, Faculty of Engineering
Yasuhiko Kaneko Director, Department of Cancer Chemotherapy, Saitama Cancer Center Hospital
Akinori Kimura Professor, Tokyo Medical and Dental University
Ikuko Kondo Professor, Ehime University School of Medicine
Hiroshi Masumoto Research Associate, Nagoya University
Fumihiko Matsuda Assistant Professor, Kyoto University
Tetsuro Miki Assistant Professor, Osaka University Medical School
Yasufumi Murakami Senior Research Scientist, Tsukuba Life Science Center (RIKEN)
Yutaka Nakahori Associate Professor, The University of Tokyo
Yusuke Nakamura Professor, The University of Tokyo
Norio Niikawa Professor, Nagasaki University School of Medicine
Misao Ohki Chief, Radiobiology Division, National Cancer Center Research Institute
Yoshiyuki Sakaki Professor, The University of Tokyo
Nobuyoshi Shimizu Professor, Keio University School of Medicine
Shoji Tsuji Professor, Niigata University
A2. Project Team 2: cDNA Analysis
Dai Ayusawa Professor, Yokohama City University
Yukihiro Eguchi Director, Research Institute, Mitsui Knowledge Industry Co., Ltd.
Seishi Kato Chief Researcher, Sagami Chemical Research Center
Yuji Kohara Associate Professor, National Institute of Genetics
Kenichi Matsubara Professor, Director, Institute for Molecular and Cellular Biology, Osaka University
Tatsuo Nakayama Professor, Miyazaki Medical College
Nobuo Nomura Labolatory Head, Kazusa DNA Research Institute
Kousaku Okubo Associate Professor, Osaka University
Kazunori Shimada Professor, Osaka University, Research Institute for Microbial Diseases
Sumio Sugano Associate Professor, The University of Tokyo
Ei-ichi Takahashi Deputy Director, Otsuka Pharmaceutical Co., Ltd.
Mitsuaki Yoshida Professor, The University of Tokyo
A3. Project Team 3: Technology Development and Model Organisms
Tatsuo Abe Professor, Kyoto Prefectural University of Medicine
Yasuhisa Adachi Research Associate, Kyoto University
Yoshinobu Baba Senior Lecturer, Kobe Pharmaceutical University
Masao Doi Professor, Nagoya University
Hisao Fujisawa Professor, Kyoto University
Yoshihide Hayashizaki Chief Scientist, The Institute of Physical and Chemical Research (RIKEN)
Momoki Hirai Professor, The University of Tokyo
Toshimichi Ikemura Professor, National Institute of Genetics
Kyoko Kohno Assistant Professor, Kyoto Pharmaceutical University
Yoichi Matsuda Senior Researcher, National Institute of Radiological Sciences
Naotake Ogasawara Professor, Nara Institute of Science and Technology
Michio Oishi Director, National Institute of Bioscience and Human Technology
Katsuzumi Okumura Associate Professor, Mie University
Akira Suyama Associate Professor, The University of Tokyo
Michihiro C. Yoshida Professor, Hokkaido University
Hiroshi Yoshikawa Professor, Dean, Nara Institute of Science and Technology
(Coinvestigators of Bacillus subtilis genome project)
Yasutaro Fujita Professor, Fukuyama University
Yasuo Kobayashi Professor, Tokyo University of Agriculture and Technology
Yoshito Sadaie Associate Professor, National Institute of Genetics
Junichi Sekiguchi Prodessor, Shinshu University
Hideo Takahashi Professor, The University of Tokyo
Teruo Tanaka Professor, University of Tokai
Kunio Yamane Professor, University of Tsukuba
Grant-in-Aid for Scientific Research on Priority Area "Genome
Informatics"
Principal Investigator
Minoru Kanehisa Professor, Kyoto University
B0. Coordination Committee
Akira Ishihama Professor, National Institute of Genetics
Katsumi Isono Professor, Kobe University
Akira Ito Chief, Department of Physics, Japanese Foundation for Cancer Research
Minoru Kanehisa Professor, Kyoto University
Kenichi Matsubara Professor, Director, Institute for Molecular and Cellular Biology, Osaka University
Shigeki Mitaku Professor, Tokyo University of Agriculture and Technology
Setsuo Ohsuga Professor, Waseda University
Yoshiyuki Sakaki Professor, The University of Tokyo
Mutsuo Sekiguchi Professor, Kyushu University
Nobuyoshi Shimizu Professor, Keio University School of Medicine
Yoshiaki Suzuki Professor, National Institute for Basic Biology
Toshihisa Takagi Professor, The University of Tokyo
Mituru Takanami Director, Kazusa DNA Research Institute
Kazuo Ushijima Professor, Kyushu University
Akinori Yonezawa Professor, The University of Tokyo
Hiroshi Yoshikawa Professor, Dean, Nara Institute of Science and Technology
B1. Project Team: Genome Informatics
Yutaka Akiyama Associate Professor, Kyoto University
Tatsuya Akutsu Associate Professor, Gunma University
Asao Fujiyama Associate Professor, National Institute of Genetics
Osamu Gotoh Senior Researcher, Saitama Cancer Center Research Institute
Masami Hagiya Associate Professor, The University of Tokyo
Yuzuru Husimi Professor, Saitama University
Hiroshi Imai Associate Professor, The University of Tokyo
Masaharu Isoyama Reserch Chemist, Protein Reserch Foundation
Minoru Kanehisa Professor, Kyoto University
Yuji Kohara Associate Professor, National Institute of Genetics
Satoru Kuhara Associate Professor, Kyushu University
Shinsei Minoshima Assistant Professor, Keio University School of Medicine
Shigeki Mitaku Professor, Tokyo University of Agriculture and Technology
Satoru Miyano Professor, Kyushu University
Hirotada Mori Associate Professor, Nara Institute of Science and Technology
Takaaki Nishioka Associate Professor, Kyoto University
Naotake Ogasawara Professor, Nara Institute of Science and Technology
Akira Suyama Associate Professor, The University of Tokyo
Toshihisa Takagi Professor, The University of Tokyo
Akinori Yonezawa Professor, The University of Tokyo
B2. Individual Projects: Genome Informatics
Hideo Matsuda Associate Professor, Osaka University
Kenta Nakai Associate Professor, Osaka University
Yoshimasa Takahashi Associate Professor, Toyohashi University of Technology
Teruo Yasunaga Associate Professor, Osaka University
Takashi Yokomori Associate Professor, University of Electro-Communications
B3. Unofficial Projects: Genome Informatics
Kiyoshi Asai Senior Researcher, Electrotechnical Laboratory
Masato Ishikawa Senior Engineer, Matsushita Electric Industrial Co.,Ltd.
Hiroshi Mizushima Head, National Cancer Center Research Institute
Haruki Nakamura Reserch Director, Biomolecular Engineering Reserch Institute
Kotoko Nakata Head, National Institute of Health Sciences
Ken Nishikawa Research Director, Protein Engineering Research Institute
Yasubumi Sakakibara Researcher, Fujitsu Laboratories Ltd.
Takeshi Shinohara Professor, Kyushu Institute of Technology
Hideaki Sugawara Chief, The Institute of Physical and Chemical Research (RIKEN)
Takao Terano Associate Professor, The University of Tsukuba
C. Steering Committee, Human Genome Center
Mitsuaki Yoshida Professor, Institute of Medical Science, The University of Tokyo
(Chairman)
Kenichi Arai Professor, Institute of Medical Science, The University of Tokyo
Kazushige Hirosawa Professor, Director, Institute of Medical Science, The University of Tokyo
Hideo Ikeda Professor, Institute of Medical Science, The University of Tokyo
Yoichiro Iwakura Professor, Institute of Medical Science, The University of Tokyo
Shiro Kanegasaki Professor, Institute of Medical Science, The University of Tokyo
Yusuke Nakamura Professor, Institute of Medical Science, The University of Tokyo
Yoshiyuki Sakaki Professor, Institute of Medical Science, The University of Tokyo
Masabumi Shibuya Professor, Institute of Medical Science, The University of Tokyo
Toshihisa Takagi Professor, Institute of Medical Science, The University of Tokyo
Tadashi Yamamoto Professor, Institute of Medical Science, The University of Tokyo
Takashi Gojobori Professor, Director, Center for Information Biology, National Institute of Genetics
Chihiro Hirotsu Professor, The University of Tokyo
Minoru Kanehisa Professor, Kyoto University
Isao Karube Professor, The University of Tokyo
Kenichi Matsubara Professor, Director, Institute for Molecular and Cellular Biology, Osaka University
Atsushi Miyajima Professor, The University of Tokyo
Shunji Natori Professor, The University of Tokyo
Misao Ohki Chief, Radiobiology Division, National Cancer Center Research Institute
Hiroto Okayama Professor, The University of Tokyo
Kazukiyo Onodera Professor, The University of Tokyo
Akira Suyama Associate Professor, The University of Tokyo
Masayuki Yamamoto Professor, The University of Tokyo
Akinori Yonezawa Professor, The University of Tokyo
H. HUGO, Japan
Toshihiko Eki Senior Scientist, The Institute of Physical and Chemical Research
Norio Fujiki Emeritus Professor, Fukui Medical School
Asao Fujiyama Associate Professor, National Institute of Genetics
Yoshimitsu Fukushima Professor, Shinshu University School of Medicine
Kenshi Hayashi Professor, Kyushu University
Tasuku Honjo Professor, Kyoto University
Tada-aki Hori Director, Genome Reserch Group, National Institute of Radiological Sciences
Yoji Ikawa Professor, Tokyo Medical and Dental University
Joh-E Ikeda Professor, Tokai University School of Medicine
Katsumi Isono Professor, Kobe University
Minoru Kanehisa Professor, Kyoto University
Yasuhiko Kaneko Director, Department of Cancer Chemotherapy, Saitama Cancer Center Hospital
Seishi Kato Chief Researcher, Sagami Chemical Research Center
Yuji Kohara Associate Professor, National Institute of Genetics
Ikuko Kondo Professor, Ehime University School of Medicine
Kenji Makino Professor, Science University of Tokyo
Kenichi Matsubara Professor, Director, Institute for Molecular and Cellular Biology, Osaka University
Tetsuro Miki Assistant Professor, Osaka University Medical School
Yasuo Nakagome Visiting Professor, Juntendo University, School of Medicine
Yusuke Nakamura Professor, The University of Tokyo
Norio Niikawa Professor, Nagasaki University School of Medicine
Susumu Nishimura Senior Executive Director, Banyu Tsukuba Research Institute
Misao Ohki Chief, Radiobiology Division, National Cancer Center Research Institute
Michio Oishi Director, National Institute of Bioscience and Human Technology
Kazukiyo Onodera Professor, The University of Tokyo
Yoshiyuki Sakaki Professor, The University of Tokyo
Nobuyoshi Shimizu Professor, Keio University School of Medicine
Haruo Sugano Director Emeritus, Japanese Foundation for Cancer Research
Mituru Takanami Director, Kazusa DNA Research Institute
Kumao Toyoshima President, The Center for Adult Diseases, Osaka
Akiyoshi Wada DIrector, Segami Chemical Reserch Center
Shoji Tsuji Professor, Niigata University
Mitsuaki Yoshida Professor, The University of Tokyo
Hiroshi Yoshikawa Professor, Dean, Nara Institute of Science and Technology
M. Project Officers at the Ministry of Education, Science and Culture (MESC)
Hajime Endo Director, Reserch Aid Division, Ministry of Education, Science and Culture (Monbusho)
Akira Inoue Director, Grant-in-Aid Planning Office, Research Aid Division, Ministry of Education, Science and Culture (Monbusho)
Orie Kishimoto Official Grant-in-Aid Planning Office, Ministry of Education, Science and Culture (Monbusho)
S. Project Officers at the Science and Technology Agency (STA)
Makoto Kumamoto Director, Life Science Division, Science and Technology Agency
Makoto Furunishi Deputy Director, Life Sciences Division, Science and Technology Agency
Izumi Honma Director, Cancer Reserch, Science and Technology Agency
S. Ad-hoc Committee on Human Genome Analysis under the Council for
Science and Technology
Wataru Mori Executive Member, Council for Science and Technology (Chairman)
Tada-aki Hori Director, Genome Reserch Group, National Institute of Radiological Sciences
Kuniaki Hosono Director, Molecular Biology Department, National Institute of Bioscience and Human Technology
Kenichi Matsubara Professor, Director, Institute for Molecular and Cellular Biology, Osaka University
Yuzou Minobe Director, Department of Molecular Biology, National Institute of Agrobiological Resources, MAFF
Masami Muramatsu Professor, Saitama Medical School and Advisory Resercher, Institute of Physical and Chemical Reserch
Akira Oya Emeritus Member, National Institute of Health,
Takeo Sekiya Chief, Oncogene Division, National Instisute of Health
Haruo Sugano Director Emeritus, Japanese Foundation for Cancer Research
Research Projects
A1. Physical and Genetical Analysis
Asao Fujiyama Construction and ordering of human chromosome specific DNA database libraries
Kenshi Hayashi Development of methods for a large scale screening of diversity of human genome
Takashi Imai Physical mapping of human chromosomes using YAC clones
Hidetoshi Inoko Cloning and gene characterization of the human MHC (major histocompatibility complex) region
Fuyuki Ishikawa Molecular study of human telomeric regions
Masaharu Isobe Genome analysis of human chromosome 14
Yasuhiko Kaneko Chromosome abnormalities and genetic changes in cancer
Akinori Kimura Identification of major gene for hypertrophic cardiomyopathy and analysis of chromosome 18
Ikuko Kondo Genetic studies on psycho-neurologic diseases
Hiroshi Masumoto The molecular structure and function of the centromeric alphoid DNA loci on human chromosome 21
Fumihiko Matsuda Physical mapping of the human immunoglobulin heavy-chain variable region genes
Tetsuro Miki Human genome projects and molecular genetic analysis of aging and dementia
Yasufumi Murakami Analysis of human genome structure
Yutaka Nakahori Molecular genetics of sex chromosomes
Yusuke Nakamura Genome analysis of human chromosome 8
Norio Niikawa Positional cloning of the putative gene for transient abnormal myelopoiesis, and molecular analysis of a 21q11-q12 region
Misao Ohki Physical mapping of the long arm of human chromosome 11
Yoshiyuki Sakaki Physical analysis of chromosome 21
Nobuyoshi Shimizu Human genome analysis using chromosome sorting
Shoji Tsuji Positional cloning of genes for neurologic diseases
A2. cDNA Analysis
Dai Ayusawa Enrichment of rare cDNA species and normalization of cDNA clones
Yukihiro Eguchi Development of software tools for genome project
Seishi Kato Construction of human full-length cDNA bank
Yuji Kohara Systematic analysis of C. elegans cDNA
Kenichi Matsubara Structural and functional analyses of the human genome
Tatsuo Nakayama Approach to protein catalog
Nobuo Nomura Trial of large scale sequencing of full length cDNA
Kousaku Okubo Body mapping of human genes
Kazunori Shimada Classification of ESTs corresponding to unidentified genes
Sumio Sugano Development of new methods for construction of cDNA library; Sequencing of cDNA clones
Ei-ichi Takahashi Human genome mapping by FISH
Mitsuaki Yoshida Analysis of T-cell specific cDNA library
A3. Technology Development and Model Organisms
Tatsuo Abe Improvement of fluorescent in situ hybridization (FISH) for gene mapping
Yasuhisa Adachi Genome analysis of S. pombe
Yoshinobu Baba Development of capillary electrophoretic technology for human genome analysis
Masao Doi Physico-chemical study of the new separation technique of large DNA
Hisao Fujisawa Structural analysis of a giant DNA by phage DNA packaging systems
Yoshihide Hayashizaki High-speed genome mapping using RLGS method and its application to positional cloning
Momoki Hirai New techniques for cytogenetic mapping
Toshimichi Ikemura Development of methods to analyse a large scale G+C% mosaic structures of the human genome
Kyoko Kohno Development of the yeast host-YAC vector system for stavilization of unstable YAC clones
Yoichi Matsuda Application of FISH in genome analysis of the mouse and human-mouse comparative mapping
Naotake Ogasawara Complete sequencing of B. subtilis chromosome
Michio Oishi Development of a novel differentiation cloning method and an equalized cDNA library
Katsuzumi Okumura Analysis of mammalian genome by fluorescence in situ hybridization
Akira Suyama Contig map construction by random oligonucleotide hybridization fingerprints
Michihiro C. Yoshida Development of new technology for FISH
Hiroshi Yoshikawa Small genome sequencing
Yasutaro Fujita Analysis of Bacillus subtilis genome: assigned region, sacS (333') ~ gnt (344')
Yasuo Kobayashi Sequencing and analysis of Bacillus subtilis genome
Yoshito Sadaie Molecular genetics of Bacillus subtilis
Junichi Sekiguchi Nucleotide sequencing of the hsdC - sspE region of Bacillus subtilis chromosome
Hideo Takahashi Genome analysis of Bacillus subtilis
Teruo Tanaka Study on the development of DNA sequencing
Kunio Yamane A 230 kb nucleotide seqence determination around the alpha-amylase gene (amyE) on Bacillus subtilis choromosome
B1. Genome Informatics
Yutaka Akiyama Development of chromosome sequence management system
Tatsuya Akutsu Methods for finding a common pattern between three-dimensional protein structures
Asao Fujiyama Designing and application of human gene database
Osamu Gotoh Development of profile database and related algorithms
Masami Hagiya Evaluation and application of biological system simulation using knowledge bases
Yuzuru Husimi Studies on representation of mutants spectrum
Hiroshi Imai Sequential and parallel algorithms for generalized string search and three-dimensional structural search
Masaharu Isoyama Construction of a knowledge database for proteins
Minoru Kanehisa Knowledge base of molecular information network in a cell
Yuji Kohara An expression map database of the C.elegans genome
Satoru Kuhara Encyclopedia of gene, SPA (signaling pathway database)
Shinsei Minoshima An integerated database system for input and serch of human genome mapping data
Shigeki Mitaku Structure prediction of membrane proteins
Satoru Miyano Parallel knowledge acquisition from genome data
Hirotada Mori Construction of genome database of E.coli and analysis of dynamics in chromosomal structure
Takaaki Nishioka Amino acid sequence motifs responsible for the recognition of chemical structures
Naotake Ogasawara Analysis of Bacillus subtilis genome information
Akira Suyama A special-purpose computer for sequence alignment
Toshihisa Takagi Development of a retrial environment to integrate genome database
Akinori Yonezawa RNA secondary structure prediction using highly parallel computers
B2. Genome Informatics
Hideo Matsuda Development of parallel multi-analysis system on genomic information using maximum likelihood
Kenta Nakai Improvement of a knowledge-based system for the prediction of subcellular localization sites of proteins
Yoshimasa Takahashi Studies on algorithms for three-dimensional structural feature search in motif identification
Teruo Yasunaga Shortening turn around time of homology search by simple parallel processing using several workstations
Takashi Yokomori Development of protein structure prediction system based on grammatical inference algorithm
B3. Genome Informatics
Kiyoshi Asai Genome informatics using stochastic models
Masato Ishikawa Genome analysis with parallel inference technology
Hiroshi Mizushima Transcription factor binding site searching program using transcription factor database
Haruki Nakamura Structure modeling of proteins
Kotoko Nakata Genetic sequence analyses and protein structure analyses
Ken Nishikawa Updating the protein mutant database
Yasubumi Sakakibara Modeling genome data with stochastic grammars
Takeshi Shinohara Fast pattern matching algorithm for genome data
Hideaki Sugawara Data capturing and management in a genome project
Takao Terano Development of a multistrategy learning model based on analogical reasoning and its application to the prediction of protein functions