Ministry of Education, Science and Culture, Japan Human Genome Program List of Investigators FY 1994


Grant-in-Aid for Creative Basic Research "Human Genome Analysis"

Principal Investigator

Kenichi Matsubara	Professor, Director, Institute for Molecular and Cellular Biology, Osaka University

A0. Coordination Committee

Asao Fujiyama		Associate Professor, National Institute of Genetics
Takashi Gojobori	Professor, Director, DNA Research Center, National Institute of Genetics
Katsuyuki Hashimoto	Chief, Division of Genetic Resources, National Institute of Health
Kazushige Hirosawa	Professor, Director, Institute of Medical Science, The University of Tokyo
Tada-aki Hori		Director, Division of Genetics, National Institute of Radiological Sciences
Yoji Ikawa		Professor, Tokyo Medical and Dental University
Akira Ishihama		Professor, National Institute of Genetics
Minoru Kanehisa		Professor, Kyoto University and The University of Tokyo
Kenichi Matsubara	Professor, Director, Institute for Molecular and Cellular Biology, Osaka University
Yuzou Minobe		Director, Department of Genetic Resources I, National Institute of Agrobiological Resources, MAFF
Shiro Miwa		Director, Okinaka Memorial Institute for Medical Research
Masami Muramatsu	Professor, Saitama Medical School
Keiko Nakamura		Deputy Director-General, Biohistory Research Hall
Yusuke Nakamura		Chief, Department of Biochemistry, Japanese Foundation for Cancer Research
Shigetada Nakanishi	Professor, Kyoto University
Susumu Nishimura	Executive Director, Banyu Tsukuba Research Institute
Misao Ohki		Chief, Radiobiology Division, National Cancer Center Research Institute
Hiroto Okayama		Professor, The University of Tokyo
Yoshiyuki Sakaki	Professor, The University of Tokyo
Haruo Sugano		Director Emeritus, Japanese Foundation for Cancer Research
Nobutaka Takahashi	Exective Director, Institute of Physical and Chemical Research (RIKEN)
Fumimaro Takaku		President, International Medical Center of Japan
Mituru Takanami		Director, Kazusa DNA Research Institute
Masaaki Terada		Director, National Cancer Center Research Institute
Jun-ichi Tomizawa	Director-General, National Institute of Genetics
Kumao Toyoshima		President, The Center for Adult Diseases, Osaka
Mitsuaki Yoshida	Professor, The University of Tokyo
Hiroshi Yoshikawa	Professor, Dean, Nara Institute of Science and Technology

A1. Project Team 1: Physical and Genetical Analysis

Asao Fujiyama		Associate Professor, National Institute of Genetics
Kenshi Hayashi		Professor, Kyushu University
Takashi Imai		Research Associate, Japanese Foundation for Cancer Research
Hidetoshi Inoko		Professor, Tokai University School of Medicine
Fuyuki Ishikawa		Associate Professor, Tokyo Institute of Technology
Masaharu Isobe		Associate Professor, Toyama University, Faculty of Engineering
Yasuhiko Kaneko		Director, Department of Cancer Chemotherapy, Saitama Cancer Center Hospital
Akinori Kimura		Associate Professor, Kyushu University
Ikuko Kondo		Professor, Ehime University School of Medicine
Hiroshi Masumoto	Research Associate, Nagoya University
Fumihiko Matsuda	Assistant Professor, Kyoto University
Tetsuro Miki		Assistant Professor, Osaka University Medical School
Yasufumi Murakami	Senior Research Scientist, Tsukuba Life Science Center (RIKEN)
Yasuo Nakagome		Professor, The University of Tokyo
Yusuke Nakamura		Chief, Department of Biochemistry, Japanese Foundation for Cancer Research
Norio Niikawa		Professor, Nagasaki University School of Medicine
Misao Ohki		Chief, Radiobiology Division, National Cancer Center Research Institute
Yoshiyuki Sakaki	Professor, The University of Tokyo
Nobuyoshi Shimizu	Professor, Keio University School of Medicine
Shoji Tsuji		Professor, Niigata University

A2. Project Team 2: cDNA Analysis

Dai Ayusawa		Associate Professor, The University of Tokyo
Yukihiro Eguchi		Director, Research Institute, Mitsui Knowledge Industry Co., Ltd.
Seishi Kato		Chief Researcher, Sagami Chemical Research Center
Yuji Kohara		Associate Professor, National Institute of Genetics
Kenichi Matsubara	Professor, Director, Institute for Molecular and Cellular Biology, Osaka University
Tatsuo Nakayama		Professor, Miyazaki Medical College
Nobuo Nomura		Chief, Kazusa DNA Research Institute
Kousaku Okubo		Associate Professor, Osaka University
Kazunori Shimada	Professor, Osaka University, Research Institute for Microbial Diseases
Sumio Sugano		Associate Professor, The University of Tokyo
Ei-ichi Takahashi	Deputy Director, Diagnostic Research Institute, Otsuka Pharmaceutical Co., Ltd.
Mitsuaki Yoshida	Professor, The University of Tokyo

A3. Project Team 3: Technology Development and Model Organisms

Tatsuo Abe		Professor, Kyoto Prefectural University of Medicine
Yasuhisa Adachi		Research Associate, Kyoto University
Yoshinobu Baba		Senior Lecturer, Kobe Pharmaceutical University
Masao Doi		Professor, Nagoya University
Hisao Fujisawa		Professor, Kyoto University
Yoshihide Hayashizaki	Research Scientist, The Institute of Physical and Chemical Research (RIKEN)
Momoki Hirai		Professor, The University of Tokyo
Toshimichi Ikemura	Professor, National Institute of Genetics
Fumio Imamoto		Professor, Kyoto Pharmaceutical University
Yoichi Matsuda		Senior Researcher, National Institute of Radiological Sciences
Naotake Ogasawara	Professor, Nara Institute of Science and Technology
Michio Oishi		Professor, Director, Institute of Molecular and Cellular Biosciences, The University of Tokyo
Katsuzumi Okumura	Associate Professor, Mie University
Akira Suyama		Associate Professor, The University of Tokyo
Michihiro C. Yoshida	Professor, Hokkaido University
Hiroshi Yoshikawa	Professor, Dean, Nara Institute of Science and Technology

(Coinvestigators of Bacillus subtilis genome project)
Yasutaro Fujita		Professor, Fukuyama University
Yasuo Kobayashi		Professor, Tokyo University of Agriculture and Technology
Yoshito Sadaie		Associate Professor, National Institute of Genetics
Hideo Takahashi		Professor, The University of Tokyo
Teruo Tanaka		Professor, University of Tokai
Kunio Yamane		Professor, University of Tsukuba

Grant-in-Aid for Scientific Research on Priority Area "Genome Informatics"

Principal Investigator

Minoru Kanehisa		Professor, Kyoto University and The University of Tokyo

B0. Coordination Committee

Akira Ishihama		Professor, National Institute of Genetics
Katsumi Isono		Professor, Kobe University
Akira Ito		Chief, Department of Physics, Japanese Foundation for Cancer Research
Minoru Kanehisa		Professor, Kyoto University and The University of Tokyo
Kenichi Matsubara	Professor, Director, Institute for Molecular and Cellular Biology, Osaka University
Shigeki Mitaku		Professor, Tokyo University of Agriculture and Technology
Setsuo Ohsuga		Professor, The University of Tokyo
Yoshiyuki Sakaki	Professor, The University of Tokyo
Mutsuo Sekiguchi	Professor, Kyushu University
Nobuyoshi Shimizu	Professor, Keio University School of Medicine
Yoshiaki Suzuki		Professor, National Institute for Basic Biology
Toshihisa Takagi	Professor, The University of Tokyo
Mituru Takanami		Director, Kazusa DNA Research Institute
Shunichi Uchida		Director, Institute for New Generation Computer Technology (ICOT)
Kazuo Ushijima		Professor, Kyushu University
Akinori Yonezawa	Professor, The University of Tokyo
Hiroshi Yoshikawa	Professor, Dean, Nara Institute of Science and Technology

B1. Project Team: Genome Informatics

Yutaka Akiyama		Associate Professor, Kyoto University
Tatsuya Akutsu		Associate Professor, Gunma University
Asao Fujiyama		Associate Professor, National Institute of Genetics
Osamu Gotoh		Senior Researcher, Saitama Cancer Center Research Institute
Masami Hagiya		Associate Professor, The University of Tokyo
Yuzuru Husimi		Professor, Saitama University
Hiroshi Imai		Associate Professor, The University of Tokyo
Masato Ishikawa		Deputy Manager, Institute for New Generation Computer Technology (ICOT)
Minoru Kanehisa		Professor, Kyoto University and The University of Tokyo
Yuji Kohara		Associate Professor, National Institute of Genetics
Satoru Kuhara		Associate Professor, Kyushu University
Shinsei Minoshima	Assistant Professor, Keio University School of Medicine
Shigeki Mitaku		Professor, Tokyo University of Agriculture and Technology
Satoru Miyano		Professor, Kyushu University
Hirotada Mori		Associate Professor, Nara Institute of Science and Technology
Takaaki Nishioka	Associate Professor, Kyoto University
Naotake Ogasawara	Professor, Nara Institute of Science and Technology
Yasuhiko Seto		Research Manager, Protein Research Foundation
Akira Suyama		Associate Professor, The University of Tokyo
Toshihisa Takagi	Professor, The University of Tokyo
Akinori Yonezawa	Professor, The University of Tokyo

B2. Individual Projects: Genome Informatics

Setsuo Arikawa		Professor, Kyushu University
Toshimichi Ikemura	Professor, National Institute of Genetics
Hideo Matsuda		Associate Professor, Kobe University
Kenta Nakai		Research Associate, National Institute for Basic Biology
Yoshimasa Takahashi	Associate Professor, Toyohashi University of Technology
Tadao Takaoka		Professor, Ibaraki University
Teruo Yasunaga		Associate Professor, Osaka University
Takashi Yokomori	Associate Professor, University of Electro-Communications

B3. Unofficial Projects: Genome Informatics

Kiyoshi Asai		Senior Researcher, Electrotechnical Laboratory
Hiroshi Mizushima	Research Staff, National Cancer Center Research Institute
Kotoko Nakata		Head, National Institute of Health Sciences
Masao Nasu		Associate Professor, Osaka University
Koichi Niijima		Professor, Kyushu Institute of Technology
Ken Nishikawa		Research Director, Protein Engineering Research Institute
Takeshi Shinohara	Professor, Kyushu Institute of Technology
Hideaki Sugawara	Chief, The Institute of Physical and Chemical Research (RIKEN)
Takahiko Suzuki		Lecturer, Kyushu University
Takao Terano		Associate Professor, The University of Tsukuba

C. Steering Committee, Human Genome Center

Mitsuaki Yoshida	Professor, Institute of Medical Science, The University of Tokyo 
			(Chairman)
Kenichi Arai		Professor, Institute of Medical Science, The University of Tokyo
Kazushige Hirosawa	Professor, Director, Institute of Medical Science, The University of 
Tokyo
Hideo Ikeda		Professor, Institute of Medical Science, The University of Tokyo
Yoichiro Iwakura	Professor, Institute of Medical Science, The University of Tokyo
Shiro Kanegasaki	Professor, Institute of Medical Science, The University of Tokyo
Minoru Kanehisa		Professor, Institute of Medical Science, The University of Tokyo
Yoshiyuki Sakaki	Professor, Institute of Medical Science, The University of Tokyo
Masabumi Shibuya	Professor, Institute of Medical Science, The University of Tokyo
Toshihisa Takagi	Professor, Institute of Medical Science, The University of Tokyo
Tadashi Yamamoto	Professor, Institute of Medical Science, The University of Tokyo

Takashi Gojobori	Professor, Director, DNA Research Center, National Institute of 
Genetics
Chihiro Hirotsu		Professor, Faculty of Engineering, The University of Tokyo
Isao Karube		Professor, Research Center for Advanced Science and Technology, The University of Tokyo
Kenichi Matsubara	Professor, Director, Institute for Molecular and Cellular Biology, Osaka University
Yusuke Nakamura		Chief, Department of Biochemistry, Japanese Foundation for Cancer Research
Shunji Natori		Professor, Faculty of Pharmaceutical Sciences, The University of Tokyo
Misao Ohki		Chief, Radiobiology Division, National Cancer Center Research Institute
Michio Oishi		Professor, Director, Institute of Molecular and Cellular Biosciences, The University of Tokyo
Hiroto Okayama		Professor, Faculty of Medicine, The University of Tokyo
Kazukiyo Onodera	Professor, Faculty of Agriculture, The University of Tokyo
Akira Suyama		Associate Professor, College of Arts and Sciences, The University of Tokyo
Masayuki Yamamoto	Professor, Graduate School of Science, The University of Tokyo
Akinori Yonezawa	Professor, Graduate School of Science, The University of Tokyo

H. HUGO, Japan

Toshihiko Eki		Researcher, The Institute of Physical and Chemical Research
Norio Fujiki		Professor, Fukui Medical School
Asao Fujiyama		Associate Professor, National Institute of Genetics
Yoshimitsu Fukushima	Director, Saitama Children's Medical Center
Kenshi Hayashi		Professor, Kyushu University
Tasuku Honjo		Professor, Kyoto University
Tada-aki Hori		Director, Division of Genetics, National Institute of Radiological Sciences
Yoji Ikawa		Professor, Tokyo Medical and Dental University
Katsumi Isono		Professor, Kobe University
Minoru Kanehisa		Professor, Kyoto University and The University of Tokyo
Yasuhiko Kaneko		Director, Department of Cancer Chemotherapy, Saitama Cancer Center Hospital
Seishi Kato		Chief Researcher, Sagami Chemical Research Center
Yuji Kohara		Associate Professor, National Institute of Genetics
Ikuko Kondo		Professor, Ehime University School of Medicine
Kenichi Matsubara	Professor, Director, Institute for Molecular and Cellular Biology, Osaka University
Tetsuro Miki		Assistant Professor, Osaka University Medical School
Yasuo Nakagome		Professor, The University of Tokyo
Yusuke Nakamura		Chief, Department of Biochemistry, Japanese Foundation for Cancer Research
Norio Niikawa		Professor, Nagasaki University School of Medicine
Susumu Nishimura	Executive Director, Banyu Tsukuba Research Institute
Misao Ohki		Chief, Radiobiology Division, National Cancer Center Research Institute
Michio Oishi		Professor, Director, Institute of Molecular and Cellular Biosciences, The University of Tokyo
Kazukiyo Onodera	Professor, The University of Tokyo
Yoshiyuki Sakaki	Professor, The University of Tokyo
Nobuyoshi Shimizu	Professor, Keio University School of Medicine
Haruo Sugano		Director Emeritus, Japanese Foundation for Cancer Research
Mituru Takanami		Director, Kazusa DNA Research Institute
Kumao Toyoshima		President, The Center for Adult Diseases, Osaka
Shoji Tsuji		Professor, Niigata University
Akiyoshi Wada		Director, Sagami Chemical Research Center
Mitsuaki Yoshida	Professor, The University of Tokyo
Hiroshi Yoshikawa	Professor, Dean, Nara Institute of Science and Technology

M. Project Officer at the Ministry of Education, Science and Culture (MESC)

Akira Inoue		Director, Planning Office, Research Aid Division, Ministry of Education, Science and Culture (Monbusho)

S. Project Officer at the Science and Technology Agency (STA)

Makoto Furunishi	Deputy Director, Life Sciences Division, Science and Technology Agency

S. Ad-hoc Committee on Human Genome Analysis under the Council for Science and Technology

Wataru Mori		Executive Member, Council for Science and Technology (Chairman)
Takuma Gamo		Director, Department of Molecular Biology, National Institute of Agrobio Resources, MAFF
Tada-aki Hori		Director, Division of Genetics, National Institute of Radiological Sciences
Kuniaki Hosono		1Director, Molecular Biology Department, National Institute of Bioscience and Human Technology
Yoji Ikawa		Professor, Tokyo Medical and Dental University
Kenichi Matsubara	Professor, Director, Institute for Molecular and Cellular Biology, Osaka University
Susumu Nishimura	Executive Director, Banyu Tsukuba Research Institute
Akira Oya		Emeritus Member, National Institute of Health, 
Haruo Sugano		Director Emeritus, Japanese Foundation for Cancer Research

Research Projects

A1. Physical and Genetical Analysis

Asao Fujiyama		Construction and ordering of human chromosome specific DNA database libraries
Kenshi Hayashi		Development of methods for a large scale screening of diversity of human genome
Takashi Imai		Physical mapping of human chromosomes using YAC clones
Hidetoshi Inoko		Cloning and gene characterization of the human MHC (major histocompatibility complex) region
Fuyuki Ishikawa		Molecular study of human telomeric regions
Masaharu Isobe		Genome analysis of human chromosome 14
Yasuhiko Kaneko		Chromosome abnormalities and genetic changes in cancer
Akinori Kimura		Identification of major gene for hypertrophic cardiomyopathy and analysis of chromosome 18
Ikuko Kondo		Genetic studies on psycho-neurologic diseases
Hiroshi Masumoto	The molecular structure and function of the centromeric alphoid DNA loci on human chromosome 21
Fumihiko Matsuda	Physical mapping of the human immunoglobulin heavy-chain variable region genes
Tetsuro Miki		Human genome projects and molecular genetic analysis of aging and dementia
Yasufumi Murakami	Analysis of human genome structure
Yasuo Nakagome		Genome analysis of the human Y chromosome
Yusuke Nakamura		Genome analysis of human chromosome 8
Norio Niikawa		Positional cloning of the putative gene for transient abnormal myelopoiesis, and molecular analysis of a 21q11-q12 region
Misao Ohki		Scanning of genes locating in the DS region of chromosome 21
Yoshiyuki Sakaki	Physical analysis of chromosome 21
Nobuyoshi Shimizu	Human genome analysis using chromosome sorting
Shoji Tsuji		Positional cloning of genes for neurologic diseases

A2. cDNA Analysis

Dai Ayusawa		Enrichment of rare cDNA species and normalization of cDNA clones
Yukihiro Eguchi		Development of software tools for genome project
Seishi Kato		Construction of human full-length cDNA bank
Yuji Kohara		Systematic analysis of C. elegans cDNA
Kenichi Matsubara	Structural and functional analyses of the human genome
Tatsuo Nakayama		Approach to protein catalog
Nobuo Nomura		Construction and characterization of cDNA libraries harboring long cDNA inserts
Kousaku Okubo		Body mapping of human genes
Kazunori Shimada	Classification of ESTs corresponding to unidentified genes
Sumio Sugano		Development of new methods for construction of cDNA library; Sequencing of cDNA clones
Ei-ichi Takahashi	Human genome mapping by FISH
Mitsuaki Yoshida	Analysis of T-cell specific cDNA library



A3. Technology Development and Model Organisms

Tatsuo Abe		Improvement of fluorescent in situ hybridization (FISH) for gene mapping
Yasuhisa Adachi		Genome analysis of S. pombe
Yoshinobu Baba		Development of capillary electrophoretic technology for human genome analysis
Masao Doi		Physico-chemical study of the new separation technique of large DNA
Hisao Fujisawa		Structural analysis of a giant DNA by phage DNA packaging systems
Yoshihide Hayashizaki	High-speed genome mapping using RLGS method and its application to positional cloning
Momoki Hirai		New techniques for cytogenetic mapping
Toshimichi Ikemura	Development of methods to analyse a large scale G+C% mosaic structures of the human genome
Fumio Imamoto		Development of the yeast host-YAC vector system for stabilization of unstable YAC clones
Yoichi Matsuda		Mouse genome mapping with FISH method
Naotake Ogasawara	Complete sequencing of B. subtilis chromosome
Michio Oishi		Development of a novel differentiation cloning method and an equalized cDNA library
Katsuzumi Okumura	Analysis of mammalian genome by fluorescence in situ hybridization
Akira Suyama		Contig map construction by random oligonucleotide hybridization fingerprints
Michihiro C. Yoshida	Development of new technology for FISH
Hiroshi Yoshikawa	Small genome sequencing
Yasutaro Fujita		Analysis of Bacillus subtilis genome: assigned region, sacS (333') ~ gnt (344')
Yasuo Kobayashi		Sequencing and analysis of Bacillus subtilis genome
Yoshito Sadaie		Molecular genetics of Bacillus subtilis
Hideo Takahashi		Genome analysis of Bacillus subtilis
Teruo Tanaka 		Study on the development of DNA sequencing
Kunio Yamane		A 230 kb nucleotide seqence determination around the alpha-amylase gene (amyE) on Bacillus subtilis choromosome

B1. Genome Informatics

Yutaka Akiyama		Development of chromosome sequence management system
Tatsuya Akutsu		Methods for finding a common pattern between three-dimensional protein structures
Asao Fujiyama		Designing and application of human gene database
Osamu Gotoh		Development of profile database and related algorithms
Masami Hagiya		Evaluation and application of biological system simulation using knowledge bases
Yuzuru Husimi		Studies on representation of mutants spectrum
Hiroshi Imai		Sequential and parallel algorithms for generalized string search and three-dimensional structural search
Masato Ishikawa		Genome analysis with parallel inference technology
Minoru Kanehisa		Motif dictionaries of proteins and DNAs
Yuji Kohara		An expression map database of the C.elegans genome
Satoru Kuhara		Encyclopedia of gene
Shinsei Minoshima	The construction of an integrated database system with graphical user interface for search and input of human genome mapping data
Shigeki Mitaku		Structure prediction of membrane proteins
Satoru Miyano		Parallel knowledge acquisition from genome data
Hirotada Mori		Construction of genome database of E.coli and analysis of dynamics in chromosomal structure
Takaaki Nishioka	Amino acid sequence motifs responsible for the recognition of chemical structures
Naotake Ogasawara	Analysis of Bacillus subtilis genome information
Yasuhiko Seto		Construction of relational database for proteins containing literature, sequence, and knowledge data
Akira Suyama		A special-purpose computer for sequence alignment
Toshihisa Takagi	Development of a deductive object-oriented database for genome information analysis
Akinori Yonezawa	RNA secondary structure prediction using highly parallel computers

B2. Genome Informatics

Setsuo Arikawa		Knowledge acquisition from genome data by analogy and minimum description length principle
Toshimichi Ikemura	Construction of codon database and development of methods to estimate coding regions
Hideo Matsuda		Development of parallel multi-analysis system on genomic information using maximum likelihood
Kenta Nakai		Development of a novel prediction method of RNA splice sites
Yoshimasa Takahashi	Studies on algorithms for three-dimensional structural feature search in motif identification
Tadao Takaoka		Study on approximate string matching with samples
Teruo Yasunaga		Shortening turn around time of homology search by simple parallel processing using several workstations
Takashi Yokomori	Development of protein structure prediction system based on grammatical inference algorithm

B3. Genome Informatics

Kiyoshi Asai		Genome informatics using stochastic models
Hiroshi Mizushima	Transcription factor binding site searching program using transcription factor database
Kotoko Nakata		Genetic sequence analyses and protein structure analyses
Masao Nasu		Development of software for bioinformatics with GUI
Koichi Niijima		Study on high-performance neural networks for genome data analysis
Ken Nishikawa		Updating the protein mutant database
Takeshi Shinohara	Fast pattern matching algorithm for genome data
Hideaki Sugawara	Data capturing and management in a genome project
Takahiko Suzuki		Query processing on deductive databases
Takao Terano		Knowledge acquisition and utilization for analyzing genome information via case-based and analogy-based reasoning